Note: our original, deeper dive KPV blog post is here!
These links skip to: Dosing info • Purchasing info
What is the KPV Peptide?
• KPV is a tripeptide consisting of the amino acids Lysine, Proline & Valine, linked by peptide bonds.
• The peptide bonds make it signaling molecule, capable of directing cells to carry out processes.
Benefits of KPV
KPV is a potent inflammation reducer, mast cell tamer and pathogen fighter (antifungal / antimicrobial).
• Gentle immune modulator – will not overstimulate.
• Small size allows it to penetrate cells and biofilms, targeting pathogens and inflammation effectively.
Additional specifics on KPV’s actions
• Anti-inflammatory: Blocks pro-inflammatory cytokines in cells, calming systemic and localized inflammation
• Mast Cell Stabilization: Reduces histamine overload, alleviating allergies, hives, flushing, itching, and MCAS symptoms
• Antimicrobial/Antifungal: Disrupts pathogen cell membranes, effective against bacteria, Candida (more potent than Diflucan), also promising for mold, and drug-resistant microbes – works through biofilms
See also: Why Antimicrobial Peptides (KPV) are better than herbs for chronic infections.
Acetylated and Amidated version is essential
• Enhances stability, bioavailability, and effectiveness, making it more potent and longer-lasting compared to non-modified peptides.
Acetylation slows enzymes from breaking it down.
Amidation alters the charge and ‘Stickiness,’ helping it reach deeper into tissues.
It also more closely matches the peptides our bodies produce.
Who Can KPV potentially help?
Individuals with:
• Mast cell activation syndrome (MCAS), allergies, hives, flushing, or inflammatory skin conditions
• PANS/PANDAS flares or long COVID symptoms
• Gastrointestinal conditions (IBS, SIBO, Crohn’s, ulcerative colitis)
• Chronic microbial / fungal infections (bacteria, yeast, and assist with mold or Lyme treatments)
• Neurodegenerative issues (POTS, Parkinson’s, Alzheimer’s, MS)
• General inflammation, anxiety, or immune dysregulation
Skip to: Dosing info • Purchasing info
Our Experience with KPV
The following are common for other group members too. You can read many success stories in the Guides Tab at the top of our Facebook group.
- It reduced and then eliminated food reactions, gut symptoms, yeast, SIBO and bloating.
- At the end of every day, we have no bloating, something I can’t recall the last time I saw for us!
- It stopped my daughter’s red flushing that she had for over a decade with exposure to heat from sunlight and showering. Also no itchiness.
- The allergic asthma I struggled with daily for a lifetime is gone!
- My lungs have abundant oxygen – I didn’t realize other people could breathe so well!
- My sinus allergies to dust mites, pollen and many other triggers have all disappeared beginning around 2 weeks into use.
- I can even tolerate environmental fragrance exposure!
- After just one week, we expanded our diets more than we have in 3 years.
- Eliminated acne, accelerated wound healing and smoothed skin.
- It stopped and also prevented PANS Flares – our KPV PANS Protocol with pdf is in my post here.
- Our minds are clearer, calmer, less inflamed. I suspect KPV could help significantly with ADD & ADHD.
- I have no ruminating thoughts and no anxiety, even in situations where I typically would.
- After one month, my long covid induced POTS (vestibular – dizziness and lightheadedness) was also gone.
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How to Dose KPV
Microdosing is Key to Success
KPV’s short signaling duration (estimated several hours) means small, frequent doses will maximize efficacy
• In the beginning, before the longer lasting effects take hold, frequent dosing is key.
• Long-Term Effects: Epigenetic changes (weeks to months) means many benefits can last after stopping use.
General Guidelines:
• Start with microdoses (~ 50 mcg per dose)
• Aim for 3-5 daily doses for consistent signaling
• Use powder from capsules sublingually (under tongue) for best systemic effects (e.g., brain, inflammation) or in capsules for slightly more targeted GI healing.
• Tasteless but can use in drink or food if needed.
Example KPV Dosing:
All amounts are approximate — exact amount does not matter. Less is always ok!
Some begin with just a toothpick sized dose once a day to minimize die off.
• Week 1: 50 mcg (1/10th of a 500 mcg capsule) up to 5x/day (maximum 250 mcg/day).
• Weeks 2-5: Gradually increase to 125 mcg (1/4 capsule) up to 4x/day, reduce if die off or irritability occurs. (max. 500 mcg/day)
• Weeks 6-8: Adjust as needed, typically not more than 1 cap per day, still divided 3x if possible
• Month 3: Begin to experiment with less
• Month 4+: if remain symptom free, move toward a maintenance dose of ~50 mcg 1-2x/day (AM/PM)
•••
For this peptide (and many others) duration of steady use matters more than specific quantity used. It’s also proven to be effective at even a nanodose.
The dosing on the bottle is not to be taken as rule per Integrative Peptides.
•••
Spray Version Microdosing: ~250 mcg per spray.
- Non preferred method, not as exact & difficult to nanodose if needed.
- An eye dropper will give you ~100 mcg/drop
- Dilute with water for microdosing
- 50 mcg = 1 drop of 50/50 diluted solution
- Note: Group members do not always have equal benefits with the spray – capsules are highly recommended
Spray is good for topical use (bug bites, acne..) although capsules work for these issues too!
Where to Buy KPV
• Recommended Source: Integrative Peptides (integrativepeptides.com/product/kpv/).
• Acetylated/amidated capsules (500 mcg)
• Price: ~$135 after SAVE10 coupon (10% off any order).
• Free shipping in the USA
• International shipping is also available
*Resellers can’t sell for less and we’ve gotten reports of what seem like fake products so ordering from them is always best.
• Integrative Peptides Spray option (~250 mcg / spray): integrativepeptides.com/product/kpv-ultra-oral-spray/
**No other brands of KPV including compounding pharmacies are Acetylated or Amidated**
These tend to have a lower efficacy, reported by our group members.
If you want them anyway – here are some:
• Biolab
• Coupon code: RESTORE for a discount
https://mybiolabshop.com/peptides/197-kpv-150-mcg-60-capsules.html
Limitless
Discount Code: QUALITY for 20% off
Capsules: https://www.limitlesslifenootropics.com/product/kpv-250mcg-capsules-60/ – price comparable to IP but not acetylated or Amidated
Vial version: https://www.limitlesslifenootropics.com/product/kpv/
(you will need to reconstitute – buy a spray kit)
See this page for the spray kit info: https://diaryofrecovery.com/buy
Die-Off Management, if needed:
Symptoms below indicate rapid pathogen death.
It’s best to reduce your doses and/or pulse (take breaks)
• Start Low, Go Slow: Best practice to prevent it from occurring, especially for those with high pathogen loads.
• Support detox with hydration and ammonia-reducing strategies (e.g., 1/4 cap BH4 our post here Detox the Die-Off).
• Use Acid Reduction Strategies from above post and if taking KPV sublingually gives you heartburn, try it inside another capsule instead – people report that stops the issue.
— If you need more help, the Gastric Mucin Bioregulator, Gastrogen is excellent at stopping acid reflux even for tough cases. See here for more.
• Use binders like activated charcoal (1 hour before or 2 hours after meals) to support detox. (Our pick)
• Can Combine with Larazotide Acetate: Temporarily closes gut tight junctions, reducing die-off from escaping the gut (see our post Larazotide Acetate Info).
• For further help, consider Liver or Kidney Support with these Bioregulator Peptides (read more about them here)
Links to purchase:
Discount code for Vita-stream is BIOREG10 for 10% off, free shipping
Key Tips for Success
• Powder used sublingually vs. inside a capsule: Experiment to find what works best for you, both are excellent! We do not recommend injections.
• Monitor and Adjust: If no results, increase dose slightly or consider if die-off is masking benefits.
• Support Detox: Use binders and hydration to manage die-off; symptoms may mimic pathogen-related issues.
• Long-Term Use: Pulsing is not required but most don’t need KPV indefinitely.
After using for several months, benefits can last weeks to months after stopping. Microdosing for maintenance is helpful.
Watch this video for additional dosing ideas & more:
Community Support:
Join the Diary of Recovery Facebook Group for shared experiences and updates.
Quick recap:
• Visit our comprehensive KPV guide for more in depth info, stories from others and more:
• For our complete KPV for PANS, MCAS and chronic illness protocol, see this page: https://diaryofrecovery.com/pans
• Use our Digital Mind Tool
For fully Customized help. See how users are raving about it here:
• See our Resources Page for much more Peptide related content including an FAQ:
Thank you for stopping by!
Diary of Recovery 