We also have an updated NAD+ post (more focused on mitochondria, not Long COVID / mast cells) if you’re interested!
Also a quick note: for NAD+ to work, it really needs to be pharma grade. How to easily obtain it for affordable price is in both posts.
As heavy on my brain as a dense San Francisco fog, a long COVID haze was my perpetual weather for nearly 2 years.
My symptoms, described in my recent recovery post were:
PEM (post exertional malaise), fatigue, breathlessness, brain fog, pounding heartbeat, internal body tremors, dysautonomia, POTS (dizziness, lightheaded) MCAS (severe life altering new allergies – indoor, outdoor and foods), GI issues, interrupted sleep and thermal dysregulation.
They lasted until NAD+, like the rising sun burning off even the murkiest day, set in motion my healing.
Measurable Improvement!
NAD+ injections, even after a long day, help keep my energy full, heartbeat steady, lungs clear, and brain processing!
My new life has brought remarkable productivity ~ who knew I’d ever be motivated to organize my pantry at 10:30pm?
And while the lack of fatigue and brain fog would have been more than enough, there’s more to tell.
Would you like MCAS with that?
Like countless others, my version of long COVID came with a side of mast cell activation syndrome (MCAS).
With MCAS, you become hyper allergic and have reactions (sinus, skin, lungs, GI system and more) to what can feel like almost everything. 😵💫
The degree to which I needed to avoid triggers was met only with head scratching even by the long covid specialists. No one could help me.
No one that is, except for the person who posted this:
Excited to learn more, I began researching NAD+ and learned it wasn’t just calming mast cells, it was curing long COVID!
What is NAD+ and how does it work?
NAD+ is nicotinamide adenine dinucleotide.
It’s one of the most abundant and crucial molecules in our body and essential to our mitochondria. We can’t live without NAD+.
It helps convert food to energy, regulates proper cell function, sleep / wake cycles, and protects us from disease and aging.
NAD+ levels significantly decline with stress, illness and age.
A video about my experience is here!
NAD+ and COVID | what we know
• COVID depletes cellular NAD+ stores.
• NAD+ is both antiviral and anti-inflammatory.
• Patients with severe COVID had significantly lower NAD+ concentrations in their organs.
• Our body cannot perform antiviral activities without NAD+ dependent enzymes.
• NAD+ is a regulator of our immune system response and can counteract its hyperactivity (and the COVID cytokine storm).
Interestingly though, there are limited mentions of NAD+ in both my mast cell and long COVID groups.
Making the connection
The few members who have posted uniformly praise NAD+ as the miracle we need, but it isn’t catching traction.
Below is one example:
This post was the first explanation I read about why it could work so well:
Here’s an excellent video that explains in-depth the above hypothesis.
NAD+ in COVID-19 and Viral Infections
More on its anti-inflammatory and immune modulatory properties
- NAD+ reduces inflammation by activating Sirtuins – proteins that regulate gene expression, cellular processes and inflammatory pathways.
- NAD+ can also modulate immune cell function. It influences the function of immune cells, such as macrophages and T cells (involved in inflammatory responses)
- This helps resolve inflammation and prevent further tissue damage
My experience with NAD+
Before I began NAD+ injections, I tried many breathing techniques, diets, and supplements in an attempt to regain my health.
Some of them helped a little, some helped more than a little, but nothing was bringing significant recovery.
I was noticing some benefits (less fatigue) from the NAD+ precursor TruNiagen but it was nothing to write about!
Because of that, it made sense to go straight to the source and try NAD+ directly.
Best administration method experimentation
I tried many versions – from home injections to nasal spray to sublingual use to capsules.
Note: the adhesive in NAD+ patches caused significant skin irritation for a few people I know, I did not try them.
I began with injections and found they are extremely effective but I was frequently finding myself with some side effects of taking too much even at extremely small doses (.1ml) which is 20mg of NAD+
My side effects from over use were, slight heart racing and leg cramps. If I felt “off” it usually only lasted under an hour. After that typical amazing benefits would come.
What I’ve found to be better was to use even less.
I switched to very small microdose injections and then to nasal spray, settling on nasal spray used sublingually as the best option!
Yes Nasal Spray, even used sublingually REALLY works!
For the most optimal balance of precision dosing (not too much, not to little) and cost, after over a year of experimenting, I found that nasal spray used sublingually is the clear winner!
One spray of pharma Grade NAD+ Nasal Spray from Ageless delivers about 30mg of NAD+
For me that’s too much. When you’re first beginning it might be the right dose.
Dosing for Sublingual use of Nasal Spray
- 1 spray in a very small cup or shot glass.
- Add a very small amount of water (1 ml)
- Pour under the tongue approx 1/3 – 1/2 of the liquid
This will give you a dose of 10-15 mg of NAD+
For reference, NAD+ sold by some companies is only 5mg per spray.
- Store remaining liquid in refrigerator for a later dose.
- Best to Pair with 500mg TMG to support methylation.
(NAD+ supplements or precursors can use up methyl groups, and DMG or TMG can help replenish them.)
Timing of Dosing
- Anytime you want to feel more energy
- Not on an empty stomach
- Daytime or early afternoon is preferred
- Evening doses are also ok – experiment
I try to take it anytime before late afternoon but it does help me sleep. When I was first starting out I took 2 doses per day and one was in the evening.
To Purchase
AgelessRx provides extremely potent, pharmaceutical NAD+ as both nasal spray and injections.
We have been using it for about 2 years.
It’s an exceptional value for the quantity of NAD+ you receive.
There are a total of 4,200mg of NAD+ in one nasal spray bottle.
We use a dose of only 15 mg (or less) at a time which lasts about 6 months.
It stays potent for more than a year in our experience.
They provide a free ‘visit’ to prescribe it which only consists of an online questionnaire and uploading a photo & drivers license.
It’s easy and straightforward. (Limited to USA)
After they approve the prescription (same day if you have no conditions they need to consult you about 🙂) they send it to a compounding pharmacy and it’s typically shipped quickly.
Tips for fast approval: It’s for yourself, and you don’t have health conditions that flag follow up questions (unless you are concerned)
The coupon code VITAL15 with give you 15% off and they always have free shipping.
You can pause or cancel the monthly subscription anytime from their website. The one time option is $140 (-15%) = $119
Ageless sells many other products and the discount code VITAL15 applies to everything (except Wegovy, Ozempic, or Grail Cancer Screening).
You do need a separate questionnaire (free “visit”) for each product but your profile info is saved.
For their page with ALL treatments available you can click on the menu at the upper right of this page:
Link to: AgelessRx Website
If not in the USA, see note and end of page.
My original injection Dosage
I ordered the injections from AgelessRx too – use same links as above info just choose injections instead of spray.
The first injection was straightforward and painless.
I used the recommended .1ml which is 20mg of NAD+
I also took a TMG supplement. I used Life Extension brand from Amazon ($10). I took 1 capsule (500mg) with each injection.
I followed with .1ml injections every day for about 2 weeks.
After that, I began skipping 2 days in between several days of using it.
I did not ever use more than .15 ml (30 mg) at a time. Sometimes I use as little as .025 ml (5 mg).
•••
To determine dosing, I simply watched my symptoms and did what I felt was best.
Overall, I used about the same as they suggested but in much smaller, more frequent doses.
If you use too much, it can result in symptoms similar to what people see from the IV (nausea, fatigue and just a general feeling of “lousy”) until some wears off and then you feel great!
•••
NAD+ injections vs. IV
Any time you reach your maximum dose of NAD+ the immediate feeling from “exciting the mitochondria” is a warm rush and some people have a higher heart rate, muscle cramps or other short lived symptoms.
The reaction is greater the more you use at once.
Generally from an IV, people report many side effects during the drip and mention that they subside afterward.
In my experience, if you use a small dose, the reactions are very minimal, but the benefits just as great. You simply need to re-dose more often.
If I use too much, the benefits are masked and I notice I feel “off.” Reddit users commonly agree.
So, my advice is, go low with dosing or you might miss the benefits!
Initial observations
Within an hour of the first injection, I felt noticeably more energetic. It was unbelievable!
It also increased my brain processing speed about 3x – both input and output! I no longer needed to watch videos on slower speed and could talk much more quickly.
Processing delays that were caused by long COVID were a huge roadblock to my healing, so NAD+ set in motion my ability to research and heal!
•••
I also didn’t need to rest after activities like I normally would and found myself organizing my pantry late that evening, which is admittedly unheard of, even before long COVID!
Another surprising benefit was I didn’t feel hunger cravings at night – which I now realize were purely an attempt to boost my extreme fatigue.
Also – no more Hanger!
When you’re hungry, your mitochondria struggle to produce energy, leading to low blood sugar and mood swings that manifest as hanger.
NAD+ steps in to fuel mitochondria, stabilize energy, and keep your brain and body calm even when meals are delayed.
The next day, I did another injection and also had no fatigue. I also noticed it makes every day feel sunny even when there are clouds – excellent mood enhancement!
Additional benefits I noticed immediately or within the first few days – a return of deep, restorative sleep, a feeling as if I was 20 years younger, improved collagen and youthfulness, eliminated dry skin on heels.
Mast Cells have calmed!
The first time I went out shopping after starting NAD+ felt like a miracle.
Long Covid made my mast cells react (with allergic asthma) to any place with dust mites / clothing and carpet. Turning something I once loved into something I dreaded.
But, I was fine!
This was going to be a whole new life for me!
I also began wondering again why MCAS benefits from NAD+ are hardly mentioned.
Phone a friend
Later that evening, wide eyed, with remarkable mental clarity, focus, motivation and energy, I told a friend about NAD+, barely able to contain the excitement!
That very night, she placed her order and has had the same results – loads of energy and no fatigue whatsoever!
Lasting results
My energy since starting the injections has held strong every day!
I’m thinking quickly and clearly, with no brain fog.
My allergies and MCAS reactions to countless foods, fragrances, chemicals, pollens, household allergens and more, are significantly reduced and my quality of life dramatically improved!
(See my long COVID recovery post for the next steps I took)
NAD+ has also helped my daughter with brain processing, task planning, motivation, and overall mood / sense of wellbeing.)
Highly Recommend!
NAD+ promised and delivered so many benefits. I couldn’t be more grateful to those who recommended it in groups and Reddit!
Now it’s my turn to “pass it on.”
NAD+ works! And I hope everyone reading this finds their very own path to recovery. 🤍
For the Long Covid symptoms that aren’t treated by NAD+, please see my post on KPV peptide. It was responsible for getting me to 100% recovered!
For anyone who is out of the USA, to get NAD+ you’ll need to look for a local source.
It needs to be shipped refrigerated / pharma grade (from a compounding pharmacy)
I would search:
NAD+ home injections – because the same companies often also sell nasal sprays.
This is NOT NAD+ IV – that is much stronger and never recommended.
You are trying to find a local equivalent to AgelessRx. (Online seller that contracts with compounding pharmacies)
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Diary of Recovery 
wondering if anyone has ordered from Canada. Thanks
I think there are some Canadian companies that sell online similar to Ageless, but I don’t know the names, I’m sorry! Maybe search on Reddit? Hope you find some!