Organs / Glands that may need more support in peri-menopause and beyond
All links direct to our pages with more information
• Ovaries – Hormone production declines significantly but they still produce small amounts our entire life – and bioregulators increase the amount!
• Pituitary – Regulates hormonal balance and endocrine function.
• Adrenals – Balance cortisol and adrenal hormone production. They take over much of the hormone production as ovary production lessens.
• Hypothalamus – Regulates neuroendocrine balance and hormonal signaling
• Pineal – Regulates circadian rhythm and supports endocrine health – essential for longevity & sleep
• Thyroid – Enhances hormone production and metabolic stability – helps with temperature regulation, energy, brain fog and sleep!
• Collagen – Promotes skin elasticity and joint mobility. This is a Bioregulator, not like taking collagen peptides.
• Brain – CogniPep or other CNS bioregulators increase memory, focus, attention, and well-being by supporting subcortical brain and blood vessels. Can help with brain fog.
Also consider supporting:
• Parathyroid (calcium metabolism and bone health)
• Muscles
• Fat Cell Metabolism (5 Amino 1 MQ)
• Sleep (DSIP)
• Mitochondria (NAD+)
Additional Supplements Mentioned:
• DHEA / Pregnenalone (hormone precursors)
• B12 (nerve & energy supoort)
• Apigenin (hot flashes – ovary & thyroid bioregulators should resolve them but I used this before I knew about them and it helped a lot!)
My Take:
I eliminated my perimenopause and menopause symptoms and improved my health far beyond baseline, with these supplements (I am not taking hormones).
Even if you’re using HRT, there’s still room to make further improvements.
Adding hormones alone doesn’t address a root cause of many of our issues — organ decline.
By improving the performance of organs, we truly can turn back the clock for our bodies!
Everything mentioned (except where noted) are what I take successfully
We all know, perimenopause and menopause can bring hot flashes, brain fog, dryness, fatigue and more.
Peptides, bioregulators, and targeted supplements offer a natural way to support our body.
They can be used as an alternative to or in addition to HRT.
A benefit of these peptides is that they are true bioregulators and bring our bodies to their own personal best, you can’t “mess them up” or overdose.
You also don’t need to frequently test to know if you’re doing it right.
Taking them will simply improve the functioning of your own glands and organs.
These precision tools work at the cellular level to ease symptoms and boost vitality.
•••
Below is our streamlined guide!
Start with a few, adjust based on your needs, and feel like yourself again 🤍
You can learn more about each of the bioregulator peptides mentioned on this page in this post:
Create a DIY Bioregulator Plan
See bottom of page for a summary of current 2025 known benefits and risks of using HRT.
Hormone Production Support
Ovaries (Ovalis)
Did you know? Ovary hormone production declines significantly but they still produce small amounts our entire life – and bioregulators can boost that amount, at any age!
• Benefits: Supports ovarian function to regulate estrogen and progesterone production, reduces menopause/perimenopause symptoms (hot flashes, brain fog, low energy, libido changes & more)
• Dose: Effective even with small doses (1/2 capsule) AM. Ongoing or repeat every few months.
• The coupon: BIOREG10 will get you 10% off – Free Shipping
Also consider the below for added benefits:
Endocrine (Hormone) & Stress Regulation
These peptides support glands that manage stress and overall endocrine balance – critical for hormonal stability as we age.
Adrenals (Adrenact)
Boosts energy, stabilizes mood, reduces fatigue, balances cortisol.
Especially important for women during menopause when adrenals take on more of the hormone production role.
• Benefits: Balances cortisol, adrenaline, and noradrenaline. Improves energy, reduces stress, supports metabolism. Enhances endocrine system function, especially as we age.
• Dose: 1/2 – 1 capsule for 30 days (or more), can repeat as needed.
• The coupon: BIOREG10 will get you 10% off – Free Shipping
Pituitary (Endocron)
Regulates hormonal balance, endocrine function and metabolism via the HPA axis.
Supports hormone regulation thereby improving energy, mood, and hormonal balance. Key for overall endocrine health.
• Dose: 1/2 – 1 capsule for 30 days (or more), can repeat as needed.
• The coupon: BIOREG10 will get you 10% off – Free Shipping
Hypothalamus (Hypotalen)
Regulates neuroendocrine balance and hormonal signaling.
Improves stress response, enhances sleep, cognition, and mood.
Supports pituitary function and overall endocrine balance, critical for aging-related hormonal decline.
• Dose: 1/2 – 1 capsule for 30 days (or more), can repeat as needed.
• The coupon: BIOREG10 will get you 10% off – Free Shipping
Metabolism and Energy
These choices support metabolic health and energy production, counteracting age-related slowdowns.
They help regulate weight, boost vitality, and enhance cellular function for both men and women.
Thyroid (ThyroPep)
Women have a higher prevalence of thyroid issues & it increases as we age.
Regulates thyroid hormone production (T3, T4), improves metabolism, energy, brain fog, temperature regulation and sleep!
Supports hypothyroidism/hyperthyroidism, can enhance weight management, and reduce fatigue.
• Dose: 1 capsule in the AM as needed
• The coupon: SAVE10 will get you 10% off & shipping is Free – from Integrative peptides
Fat Cell Metabolism & more (5-Amino-1 MQ)
Increases energy, metabolism, and fat cell burning. Inhibits NNMT enzyme, corrects fat cell metabolism, increases NAD+, activates SIRT1 longevity gene.
Boosts muscle mass, reduces cholesterol, slows cell aging, promotes stem cell growth.
Helps prevent type-2 diabetes and obesity, reduces hunger.
Noticeable energy increase, supports weight loss, reduces fat.
• Dose: 1/4 capsule in early morning (put inside another capsule)
• Coupon code: QUALITY for 20% off at Limitless Life
Mitochondria & More! (NAD+ Powerhouse to our cells)
Adding NAD+ supports our cells with the fuel our mitochondria are starving for — making peptides even more effective.
This small molecule has been a game changer for our health. Immediate energy boost, faster brain processing, no hunger cravings!
• Benefits: Boosts energy, reduces brain fog, improves sleep, enhances cognition, supports mood, promotes youthful cell function.
Nourishes mitochondria, activates sirtuins to reduce inflammation, supports DNA repair, regulates immune response abs so much more.
Benefits chronic diseases, aging, inflammation, oxidative stress, and sleep disruptions.
• Dose: varies, see below blog post
• Note: Pharma grade NAD+ is critical. See our NAD+ post for the easiest way to get it and dosing options (even sublingual works well!) only about $100 for 6 month supply
• Coupon Code, also mentioned at link above, is VITAL15 for 15% off at AgelessRx
Sleep and Longevity
These peptides enhance sleep quality and promote longevity by supporting the pineal gland and circadian rhythms.
Sleep is the ultimate foundation for hormonal balance and overall wellness!
Pineal Gland (PinealPep or endoluten)
Some believe these to be the ultimate Anti-Aging Peptides!
It provides: Regulation of circadian rhythm and management of the entire endocrine system – essential for longevity, sleep and hormonal balance.
Supports melatonin production, improves sleep-wake cycles, lengthens telomeres and reduces stress.
• Dose: 1/2 capsule in the evening as needed, breaks as desired.
PinealPep contains added Vacaular and Thymus Peptides for Deeper reach and added Immune support:
• Coupon: SAVE10 for 10% off at Integrative Peptides
Endoluten is an OG Bioregulator Peptide, strictly pineal support.
• Coupon: BIOREG10 will get you 10% off – Free Shipping
Benefits: What Can Pinealpep, Endoluten, and Epithalon Bioregulators Help With?
Backed by decades of research, mostly from Khavinson’s team. Here are some highlights:
• Circadian Rhythm and Sleep: By boosting melatonin, these pineal bioregulators restore nighttime peaks, improving sleep quality and consistency.
Users report deeper, more restorative sleep, which is crucial for mood, cognition, and recovery. In older patients, normalized melatonin circadian rhythms, reducing insomnia.
• Telomere Length and Anti-Aging: Telomerase activation extends telomeres, delaying cellular aging.
Studies show their use enables cells to surpass the Hayflick limit, potentially extending lifespan. In animal models, they increased lifespan by up to 7 years when taken intermittently.
Human trials suggest a 28–50% reduction in mortality from cardiovascular and respiratory diseases.
• Immune Function: Pineal bioregulators enhance T-cell activity and reduce immune senescence.
PinealPep’s thymus peptides amplify this, supporting lymphocyte proliferation to fight infections and maintain immune resilience, especially in older adults.
• Cardiovascular Health: Pineal bioregulators improve physical endurance and lipid metabolism in coronary patients, cutting cardiovascular mortality by 50% over 12 years.
By regulating cortisol and melatonin, these bioregulators support heart health.
• Cognitive and Mood Support: Improved circadian rhythms and reduced oxidative stress enhance cognitive clarity and mood stability.
Pineal bioregulators neuroprotective effects may lower risks of Alzheimer’s and Parkinson’s, where pineal atrophy is pronounced.
• Possible Cancer Prevention: By stabilizing DNA and reducing chromosomal aberrations, they inhibit tumor formation in mice and rats.
Its antioxidant properties further protect against oncogenic stress.
• Reproductive Health: In aging rats, pineal bioregulators restored reproductive function, likely by regulating gonadotropins (LH, FSH).
Reports of hormonal balance in humans of all ages including menopause are common.
• Vision Protection: They improve retinal function – in 90% of patients with retinal degeneration and protected rat retinas from oxidative damage, suggesting benefits for eye health.
• Metabolic Balance: In monkeys, pineal bioregulators lowered glucose and insulin levels, countering age-related pancreatic decline. This could help manage metabolic disorders like diabetes.
• Stress Resilience: Pineal bioregulators reduce corticosteroid levels, increasing stress resistance. This supports adrenal health and emotional balance, especially under chronic stress.
Delta Sleep Inducing Peptide (DSIP – Nasal Spray or sublingual)
This is for anyone who needs even more help with sleep.
Promotes deeper, more efficient sleep, reduces night waking, enhances restfulness. Increases GABA production, slows brain activity, induces relaxation, lowers inflammation in the sleep center.
• Dose: 1-2 sprays (50-100 mcg) 1-2 hours before bed; 2 sprays may prevent night waking better than 1. Sleep inertia can result if too much is used – otherwise no side effects.
• Coupon code: QUALITY for 20% off at Limitless Life
See our review post and video here
Cognitive Health
Brain / Central Nervous System (CogniPep)
This brain peptide is well loved in our community! It Supports brain function, improves cognition, mental clarity and aids emotional balance.
If you could use help maintaining sharp thinking – it’s one to consider!
Increases memory, focus, and well-being by supporting subcortical brain and blood vessels.
Reduces brain fog, improves recall. Protects against neurodegenerative diseases.
• Dose: 1/4 capsule in AM. Typically 3-5 days on, 2 days off – subject to experimentation!
Especially helpful to pair with NAD+
• coupon: SAVE10 for 10% off at Integrative Peptides – free shipping in USA, international available
See our full breakdown and video review of 4 brain peptides here.
Structural Health
These peptides support connective tissues, joints, skin, muscles, and bones – helping maintain physical strength and appearance as we age!
Collagen (Collacell)
Menopause reduces collagen due to low estrogen, causing loss of skin firmness and joint pain.
This is a Bioregulator, not to be confused with collagen peptides.
It stimulates our natural collagen production, improves skin elasticity, supports joint flexibility and bone health. Counteracts age-related collagen decline, promotes youthful appearance, and aids in tissue repair.
• How It Works:
Interacts with fibroblast DNA to boost collagen synthesis.
Improves skin tightness and joint function, per Khavinson’s studies.
It’s one of my favorite peptides!
Improves skin hydration and reduces fine lines too!
• Dose: 1/4 capsule sprinkled under the tongue 3x per day
• The coupon: BIOREG10 will get you 10% off – Free Shipping
Muscles (Gotratix)
Increases muscle health, enhances physical efficiency, reduces fatigue during intense activity.
Regulates muscle cell metabolism, improves adaptability, and provides antioxidant protection. Benefits athletes and aging individuals with muscle loss. Speeds fatigue recovery.
• Dose: 1 capsule / day for 30 days, repeat every 4 months
• The coupon: BIOREG10 will get you 10% off – Free Shipping
Parathyroid (Bonothyrk – bone health)
Strengthens bones, supports calcium regulation.
Regulates calcium and phosphorus metabolism, supports bone health, prevents osteoporosis, and maintains parathyroid function. Enhances skeletal strength and hormonal balance.
• Dose: 1/2 – 1 capsule per day, 30 days, repeat every 4-6 months.
• The coupon: BIOREG10 will get you 10% off – Free Shipping
These supplements all work together to naturally rejuvenate our organs and bring back online our own hormone production!
They have been a lifeline for many people in our group, making feeling like yourself again attainable!
Additional Supplements to Consider
DHEA/Pregnenolone
• What It Is:
Adrenal “mother hormones” converting to estrogen, progesterone, and testosterone. Natural hormonal support for menopause.
• Why Needed:
Declining levels worsen fatigue, low libido, and mood swings. Boosts vitality and hormonal balance.
• How It Works:
Binds to nuclear receptors, enhancing hormone production. Improves symptoms like hot flashes by ~20%, per studies.
• Where to Find:
Available at health stores or online (e.g., Pure Encapsulations).
5-Amino-1-MQ: Fat Cell Metabolism
• What It Is:
A peptide inhibiting NNMT for better fat metabolism. Combats menopausal weight gain.
• Why Needed:
Menopause slows fat burning, leading to stubborn midsection weight. Enhances energy and body composition.
• How It Works:
Blocks NNMT, boosting NAD+ and mitochondrial fat oxidation. Reduces fat storage.
• Where to Find more:
https://diaryofrecovery.com/2025/01/22/review/#5amino
Biolab (coupon: RESTORE) or Limitless Biotech (coupon: QUALITY).
Links to buy on this page: https://diaryofrecovery.com/buy
B12: Energy Boost
• What It Is:
Vitamin B12 for energy and neurological health.
Counters menopausal fatigue.
• Why Needed:
B12 deficiencies worsen mood, energy, and brain fog. Keeps you energized.
• How It Works:
Supports red blood cell formation and methylation reactions. Boosts energy and mood, per studies.
• Where to Find More:
Https://diaryofrecovery.com/b12
Microdose Progesterone Cream (Optional)
We do not use this – it caused acne in even the smallest microdoses.
• What It Is:
Low-dose bioidentical progesterone cream for symptom relief. Gentle hormonal support.
• Why Needed for some:
Eases insomnia, anxiety, better sleep.
• How It Works:
Binds to progesterone receptors, calming the nervous system. Reduces hot flashes, helps with sleep per studies.
• Where to Find:
This is the one we tried, it’s obviously potent! https://a.co/d/86siD14
Apigenin (Optional herb for Hot Flashes)
I no longer need this.
• What It Is:
A flavonoid with calming, anti-inflammatory effects. Reduces hot flash severity.
• How It Works:
Modulates GABA receptors and reduces oxidative stress. Also wfrecrs hormonal production
• Where to Find More:
I used this herb for many years before finding peptides! It’s still beneficial and here’s my post:
https://rkvillage.com/apigenin
How to Start:
Try a few (e.g., ovaries, ThyroPep, Adrenact) and monitor results.
Build a stack based on your symptoms.
It is very possible to see remarkable relief in a short time and symptoms get even less the longer you use them (1-2 months)
2025 Current Teachings Summarized – Combined HRT (Estrogen + Progestin)
Pros:
• Reduces menopausal symptoms (hot flashes, night sweats)
• Prevents osteoporosis, lowers fracture risk
• May reduce colorectal cancer risk
Cons:
• Slightly increases breast cancer risk (3–8 extra cases/1,000 women over 5 years)
• Small increase in ovarian cancer risk
• Higher risk of heart disease, stroke, blood clots (especially oral, in women over 60)
Estrogen-Only HRT
Pros:
• Reduces menopausal symptoms
• Prevents osteoporosis, lowers fracture risk
• May lower heart attack risk in women under 60
• No increased breast cancer risk (post-hysterectomy)
Cons:
• Increases endometrial cancer risk (if uterus intact)
• Slight increase in ovarian cancer risk (long-term use, 12+ years)
• Small increase in stroke risk
• Blood clot risk with oral forms
Diary of Recovery 