Part 1
See end of this page for a prior review we shared with parts 1 & 2 combined.
The same slides are there also.
The webinar featured Dr. Kent Holtorf discussing the use of peptides and bioregulator peptides to treat Chronic Inflammatory Response Syndrome (CIRS) and related chronic conditions.
Dr. Holtorf emphasizes accelerating CIRS treatment by addressing upstream root causes rather than relying solely on downstream binders.
Peptides dramatically shorten treatment timelines—from years to months or weeks—by fixing immune dysfunction, mitochondrial issues, and other core abnormalities.
Key emphasis is on synergistic use:
peptides and bioregulators work exceptionally well together, stacking effects without exponential side effects or interactions, unlike medications.
This synergy targets multiple systems simultaneously, making treatments more effective for complex, multisystem illnesses.
Issues with Traditional CIRS Treatment and Paradigm Shift
• Traditional approaches (e.g., binders) often fail or flare patients, leading to prolonged treatment (e.g., 8 years on binders with minimal progress).
CIRS typically stems from pre-existing immune deficiencies (e.g., from Lyme, infections, stress, or aging), not just mold exposure.
• Core abnormalities include:
Dysfunctional immune system (low TH1/high TH2 leading to suppressed natural killer cells, autoimmunity, and inflammation); mitochondrial dysfunction (preventing effective detox); T-cell exhaustion (cells present but non-responsive); immunosenescence; and barrier integrity issues (e.g., leaky gut, blood-brain barrier).
• Shift to upstream fixes:
Modulate immunity first to retrain the system, then address infections and detox. This enables the body to handle toxins naturally, reducing reliance on binders.
• Avoid long-term VIP (vasoactive intestinal peptide):
It can initially improve symptoms but suppresses TH1 further, preventing full recovery and causing crashes upon re-exposure to triggers like mold.
• Biomarkers:
Natural killer cell activity (dysfunctional despite numbers); C4a; TGF-beta (causes fibrosis and hypercoagulation—Quest labs more accurate than LabCorp).
Peptides vs. Bioregulators: Mechanisms and Synergistic Benefits
• Peptides:
Chains of up to 50 amino acids; act on cell surface receptors as signaling molecules, triggering intracellular effects and cell-to-cell communication. Often injectable (except oral BPC-157 acetate). Provide immediate effects.
• Bioregulators:
Subset of 2-4 amino acids; oral, highly absorbable, enter cells to influence epigenetics (gene activators/repressors). Slower onset but long-lasting tissue healing. Ideal for sensitive patients as starting point due to simple structure and lower rejection risk.
• Synergy:
Bioregulators prime the system slowly; peptides deliver rapid boosts. Combining them (e.g., 5-10 at once) targets multiple pathways—immune, mitochondrial, gut-brain axis—without side effects.
Dr. Holtorf routinely uses up to 10 bioregulators together for enhanced outcomes, as they heal specific tissues while peptides modulate broadly. Food-based bioregulators are viable but less precise than synthetics, which allow exact dosing and higher active levels.
• Start low with sensitive patients (e.g., toothpick dip of KPV); build up.
Protocols are not cookie-cutter—adapt based on patient response, genetics (e.g., detox SNPs), and testing (e.g., toxins in urine indicate hoarding if absent).
Specific Peptides, Bioregulators, and Applications
• Immune Modulation (Raise TH1, Lower TH2): Thymosin Alpha 1 (approved in 54 countries, safe); Thymogen Alpha 1 (more potent, with Thymalin and Thymogen); TB4 Frag (immune modulatory fragment of Thymosin Beta 4, avoids mast cell stimulation; rejuvenates heart, brain post-MI/stroke)
KPV (anti-inflammatory, boosts immunity, antimicrobial—more potent than amoxicillin for staph or Diflucan for fungus; selective against bad bacteria, supports microbiome).
• Mitochondrial Support (Essential for Detox): MOTS-c (stimulates, but avoid early if inflammation high—can worsen oxidative stress); SS-31 (heals mitochondrial lattice; doses 5-10mg 2x/week, studies up to 100mg safe)
Humanin (restores function, “makes Alzheimer’s patients human again”); PQQ, PPC, TB4. Fix mitochondria first (e.g., even via the weakest choice. CoQ10 in studies) to enable energy for detox—synergizes with binders to speed process.
• Brain and Nervous System:
Cerebrolysin, Semax (activating, nasal for brain delivery); Selank (Dr. Holtorf is a big fan—calming, immune modulator; great for stress; nasal to reach olfactory nerves/brain, but clear sinuses first to avoid interference from colonizations).
CogniPep and CerebroPep (oral bioregulators for brain function). Clear sinus colonizations (e.g., fungi, gut bugs in sinuses) before nasal peptides.
• Gut and Barrier Integrity: BPC-157 (body protective compound; gut healing, joints, brain, inflammation; oral acetate bioavailable).
Larazotide (people love it—seals leaky gut; start treatment with it for MCAS, then add KPV; from compounding pharmacy); KPV (gut anti-inflammatory); Akkermansia, Melain (restore gut-brain axis).
• Pineal/Hypothalamic-Pituitary Axis (Command Center): PineoPep (with Epitalon—restores thymus axis, influences TH1/TH2/TH17; dosing: 5 days on/2 off for 2-3 months, then break; more continuous for illness vs. 10-day anti-aging cycles).
• Thyroid (Common in CIRS): TSH unreliable due to axis dysfunction—use T3 directly. ThyroPep (bioregulator; raises T3/T4 in hypothyroid, lowers antibodies in Hashimoto’s; allows hormone dose reduction).
• Coagulation/Fibrin (Immune Activation): Heparin, lumbrokinase, nattokinase; BPC, copper. Clears fibrin buildup (e.g., from Lyme), improving nutrient/waste exchange and reducing air hunger.
• Senolytics (Clear Zombie Cells/Mitochondria): FOXO4-DRI (start 0.1-0.2mg slow); Dasatinib (25-50mg); Quercetin/Fisetin (500-1,500mg). 3 days/month continuous; clears dysfunctional cells to prevent reactions to mitochondrial boosters.
• Other Notables: GHK-Cu (connective tissue, neuropathy; subQ injections or creams for cranial-cervical instability, hypermobility; synergizes with TB4 for MCAS-aggravated ligaments). ARA-290 (neuropathy).
Rapamycin (autoimmune; low doses like 1mg 2x/week).
For parasites: KPV likely effective (antimicrobial properties).
For gastroparesis/gut issues: BPC-157, KPV, TB4 Frag, GutPep (Akkermansia, Melain)—reversed severe cases quickly.
• Detox Focus: Prioritize immune modulation and mitochondrial support—body detoxes naturally once energized. Support slow detoxers (e.g., glutathione SNPs) with peptides; avoid early MOTS-c if stuck in cell danger response stage 1.
Protocols and Patient-Specific Insights
• CIRS Protocol: Start with immune boosters (e.g., Thymogen Alpha 1, KPV, TB4 Frag), mitochondrial healers (SS-31, MOTS-c), barrier repair (BPC-157, Larazotide). Add binders later. Synergistic stacks cut timelines in half.
• MCAS: Larazotide first for leaky gut, then Melainox, KPV, other modulators before full peptides.
• Chronic Illnesses (e.g., Lyme, Long COVID, Autoimmune, Cancer): Same pathophysiology—immune/mito/coagulation dysfunction. Use stacks (e.g., 6-7 peptides at once for rapid relief); add Ivermectin, lumbrokinase for coagulation. Reversed cases like invasive bladder cancer in 2 months with multi-peptide protocols.
• General Advice: Test for root causes (infections, toxins, genetics). Protocols adaptable—AI agent in development for personalization.
Bioregulators for sensitive starters; transition to peptides. No harm in trying if diagnosis unclear—all chronic illnesses share mechanisms.
The discussion underscores peptides’ miraculous synergy in multisystem healing, with Dr. Holtorf’s book (see below to download) on updated CIRS peptide protocols available for details.
Find more!
• Parts 1 & 2 both:
For the book download and a full review of parts 1 & 2 together – see this page
• Alternately:
For a complete 218 page slide collection from Dr. Holthorf and more in depth review – see this page
Diary of Recovery 