We’ve seen TB4‑Frag noticeably speed real-world healing!
See below for comparisons to TB500, BPC-157, GLOW & KLOW (which we don’t use)
Post‑workout muscle recovery and a sprained back resolved faster with better range.
My plantar fasciitis is a thing of the past. And spider veins are surprisingly reduced! (pair with Ventfort)
Gut healing has also happened quickly and for kids – cuts, scrapes, and bug bites all resolve faster with less scarring. It has even helped soothe sore throats.
We’ve also seen everyday bruises clear faster, a signal of it’s active tissue remodeling.
We are definite fans of this healing peptide & consider it a medicine cabinet essential!
(Reminder, red / IR light therapy with the contact method can also help with healing – see our post)
What Is TB4‑Frag?
TB4‑Frag (Thymosin Beta‑4 Fragment) is the bioactive fragment of the natural peptide Thymosin Beta‑4.
It’s produced naturally in the thymus gland, platelets, and at wound sites.
The full TB4 comprises 43 amino acids, which limits oral absorption.
TB4‑Frag isolates the core segment (typically 4–7 amino acids) for better oral bioavailability.
TB4 Fragment 1-4 is the workhorse of full-length TB4
Possessing the immune-modulatory, angiogenic, healing, anti-inflammatory, cellular protective, and repair actions of full-length TB4.
TB4 Frag differentiates itself from full-length TB4 in the following ways:
- Orally active (absorbs intact) and can penetrate biofilms (small size).
- More potent antifibrotic.
- Ten times the potency of full-length TB4 by weight
- Does not stimulate mast cell activation (segment 17-23).
- Does not stimulate hair growth (segment 17-23).
Integrative Peptides has created the most bioavailable natural isomer of TB4 Frag (Acetylated and Amidated and sold as capsules or a spray)
To purchase:
For the most current Tb4 Frag links and discounts see: this page – Integrative Peptides heading.
(Sometimes their product link changes so it’s best to visit that consolidated page)
Note: TB4‑Frag Max has added thymus extract – it can be too immune stimulating for sensitive people
Dosing
This one is easy. You can’t really mess it up. We usually use a 1/4 of a capsule 2 to 3 times a day, when needed.
Experimenting is great and 1x per day, or a up to full cap for someone who wants no fuss is fine also.
If longer term use is desired, consider 1/4 cap per day.
It’s also part of our acute illness protocol:
Key Mechanisms and Benefits
TB4‑Frag supports protection, repair, and optimization across cellular processes.
Tissue repair and regeneration
- Binds to actin to drive stem cell migration, proliferation, and differentiation.
- Rebuilds damaged tissues in wounds, muscles, nerves, and organs.
- Accelerates angiogenesis for nutrient delivery and supports extracellular matrix remodeling.
This page will summarize findings!
Anti‑inflammatory and anti‑fibrotic
- Balances cytokines and inhibits NLRP3 signaling.
- Reduces myofibroblast activity to minimize inflammation and scarring, aiding chronic conditions.
Protective and antioxidant properties
- Shields cells from oxidative stress and apoptosis.
- Exhibits antimicrobial effects.
- Supports mitochondrial function for energy.
Immune modulation
- Enhances T‑cell production and antibody responses.
- Supports balanced immunity against pathogens and autoimmunity.
Neurological and cardiovascular support
- Protects neurons; promotes nerve regrowth, axonal outgrowth, and oligodendrogenesis (myelin formation).
- Fosters neurogenesis, synaptogenesis, and neurovascular remodeling.
- Aids recovery across brain, spinal cord, and peripheral nerves.
- Additional effects include support for hair growth and joint flexibility via collagen and cell mobility support.
Other domains
- Supports gut barrier integrity and mucosal healing.
- Aids bone and cartilage repair in osteoarthritis models.
- Counters age‑related TB4 decline to keep endogenous repair capacity stronger.
- Net effect: amplifies the body’s own repair for faster, more complete recovery.
Additional TB4‑Frag notes
- Supports endothelial function and micro‑vasculature health, which helps repairs hold instead of stalling.
- Harmonizes immune tone rather than pushing it, useful when chronic inflammation prevents tissues from finishing the remodeling phase.
- Hair and skin quality often improve as blood flow and matrix remodeling normalize.
Healing Tissues From Toxin Damage
What toxins do
- Toxins create oxidative stress, inflammation, and fibrosis, leaving tissues fragile and scar‑prone.
How TB4‑Frag helps
- Restores micro‑circulation, reduces fibrotic remodeling, and supports cellular regeneration.
- Neutralizes damage, reduces scarring, and promotes healthier repair.
Evidence patterns and practical read‑through
- In liver toxin models (e.g., carbon tetrachloride), TB4‑Frag mitigates injury and fibrosis.
- In lung studies (e.g., bleomycin), it helps prevent fibrosis and protects alveoli.
- Indirectly aids detoxification by enhancing cell resilience against heavy metals or bacterial toxins.
- In real life, this looks like quicker rebound after smoke, pollution, medications, alcohol, or infections.
Nerve Healing and Regeneration
Why nerves benefit
- Nerve repair depends on lowering inflammatory noise, restoring perfusion, and supplying pro‑growth cues for remyelination and connectivity.
Core neural actions
- Promotes oligodendrogenesis for myelin repair.
- Stimulates neurogenesis and supports axonal remodeling for connectivity restoration.
- Improves vascular support around nerves and remodels neurovascular units to strengthen stem‑cell niches and neural plasticity.
Peripheral nerve signals
- In peripheral neuropathy models, TB4‑Frag improves nerve conduction velocity and reduces functional deficits.
- Enhances the micro‑vessels that nourish and stabilize nerves.
Central nervous system support
- For central nervous system issues, it reduces cell loss, inflammation, and apoptosis.
- Stimulates remyelination and functional recovery.
How it helps
- As signaling and blood flow improve, people often notice steadier sensation, better activity tolerance, and fewer delayed payback days.
- These neural gains tend to stick because TB4‑Frag improves both the cellular signals and the vascular delivery that sustains them.
FAQ
Comparison to other options
KLOW is a blend of: BPC-157 — TB-500 — KPV — GHK-Cu
Instead of injecting GLOW / KLOW you can very effectively use oral capsules of: TB4-Frag, KPV and optional GHK-Cu. Get each here. (See Integrative Peptides and Limitless)
What is the difference between TB4 Frag and TB 500?
TB4 is the natural human thymosin beta‑4 peptide. TB500 is a lab-made, longer-chain analog used mainly by injection.
As capsules TB500 won’t come close to matching the bio availability of the natural isomer, Acetylated / Amidated TB4 Frag.
They aim at similar repair pathways but aren’t identical in structure or pharmacokinetics. Also TB500 has side effects (see link on safety)
Overlap: Both signal tissue repair, cell migration, angiogenesis, and inflammation modulation.
See more about safety of longer chain peptides in our post here.
Why not BPC‑157?
How BPC‑157 works, briefly
- Upregulates growth factors such as VEGF to promote angiogenesis and tissue repair, with a strong reputation around gut, tendon, and muscle support.
- Helps maintain vascular integrity and shows antioxidant activity; interacts with neurotransmitter systems (dopamine and serotonin) in ways that may feel like mood shifts for some.
Known BPC 157 concerns to consider
- Anxiety or activation that can persist beyond dosing.
- Anhedonia or flat mood in a subset.
- Mast cell activation or histamine‑type flares (itching, flushing, allergy‑like symptoms, inflammation spikes) in sensitive users.
- Occasional gut irritation or fatigue reported during or after use.
Why TB4‑Frag can be better
- Broader tissue reach with multi‑tissue regeneration, including gut mucosa, skin, ligaments and tendons, nerves and myelin, and micro‑vasculature.
- Cleaner immune tone with fewer mast‑cell or histamine‑type issues in sensitive users.
- Nervous system friendly, aligning with remyelination and neurovascular remodeling without a recurring pattern of anxiety or anhedonia in community reports.
- Practical versatility for post‑illness rebuilds, stubborn soft‑tissue repair, and gut lining restoration, with fewer caveats for continued use.
Note: TB4 (and frag), TB500, and BPC 157 all promote angiogenesis –
The body’s process of building new blood vessels from existing ones. It’s how we restore microcirculation into healing tissue so oxygen, nutrients, and immune cells can reach the area, which supports faster repair and remodeling.
Some say this could be of a concern to people with active cancer.
Others believe it could be beneficial. It requires more research to your own comfort level.
Who Would TB4-Frag Be Best For?
This list is not to suggest that TB4 Frag is the only peptide to use for these issues
For more help with your specific needs, you may want to consider our new AI tool:
TB4-Frag benefits those with inflammation, slow healing, or tissue/nerve damage.
Examples include:
• Smokers or Respiratory Toxin Victims: Regenerates lung tissue, reduces fibrosis from smoke toxins.
Applications: Ex-smokers in detoxification; anyone with lung irritation; wildfire survivors with particle exposure.
• Environmental/Occupational Toxin Exposures: Repairs organ/nerve damage from silica, asbestos, or pesticides.
Applications: Urban residents in pollution; chemical spill workers; miners with heavy metals.
• Liver Toxin Sufferers: Mitigates cirrhosis or fatty liver.
Applications: Alcohol use, acetaminophen overdoses; mold toxin cases.
• Athletes and Fitness Enthusiasts: Heals micro-tears from metabolic byproducts.
Applications: Runners with overuse; weightlifters post-steroid; yoga users with strain; CrossFitters after training.
• Elderly or Age-Related Decline: Counters natural TB4 decline for anti-aging, repairs wounds and nerves.
Aids bone/cartilage repair in osteoarthritis and much more.
• Chronic Autoimmune and Infection: Modulates immunity in Lyme, post-viral syndromes.
Applications: Long-COVID with lung/brain fog; allergy triggers; HIV tissue support.
• Neurological Conditions: Protects against neurotoxins in traumatic brain injuries, strokes, or neurodegeneration.
Applications: Concussion-prone athletes with axonal damage; Parkinson’s patients with degeneration; Autism, migraine sufferers with inflammatory flares; multiple sclerosis cases needing remyelination; spinal cord injury recovery for neurite outgrowth.
• Peripheral Neuropathy Sufferers: Improves nerve function in diabetic models by increasing myelin, vascular density, and conduction.
Applications: Diabetics with foot numbness; elderly with age-related nerve decline.
• Gut and Digestive Issues: Repairs leaky gut from toxins/bacteria.
Applications: IBS with stress; celiac intestinal healing; antibiotic microbiome disruption.
• Joint and Bone Problems: Supports cartilage in osteoarthritis, reduces arthritis inflammation.
Applications: Dancers with wear; osteoporosis fractures; rheumatoid fibrosis control.
• Skin and Eye Conditions: Accelerates burns, ulcers, corneal healing.
Applications: Diabetics with sores; acne scars; dry eye irritants.
• Cardiovascular Patients: Repairs heart post-infarction, reduces toxin clots.
Applications: High-cholesterol plaque; surgery recovery; blood thinner bruising.
Additional Specific cases
• Heart Attack (Myocardial Infarction) Patients: Promotes heart cell survival and improves cardiac function after a heart attack through cell protection and new blood vessel growth.
• Dry Eye Sufferers: Improves eye surface repair and reduces inflammation in chronic dry eye conditions.
• Chronic Kidney Disease Patients: Reduces kidney scarring from toxins or long-term illness by blocking harmful signaling pathways.
• Ulcerative Colitis Patients: Lowers gut inflammation and supports lining repair in inflammatory bowel diseases.
• Patients with Poor Leg Circulation (Peripheral Artery Disease): Enhances blood flow and muscle recovery in legs affected by blocked arteries, reducing pain and ulcers.
• Sepsis Survivors: Offers cell protection and fights infection-related organ damage to aid multi-system recovery.
• Radiation Accident Victims: Shields tissues from radiation damage and promotes healing after exposure.
• Heavy Metal Poisoning Sufferers: Protects cells from oxidative harm and supports recovery in cases of lead or mercury exposure / helpful before, during and after chelation.
• Alcoholic Neuropathy Patients: Repairs alcohol-related nerve damage in limbs by combining toxin cleanup and nerve regrowth.
• Fibromyalgia Sufferers: Eases widespread pain and inflammation while strengthening muscle and tissue resilience.
• Post-Stroke Recovery Individuals: Boosts brain blood vessel and nerve remodeling for better movement and function after a stroke.
• ALS (Amyotrophic Lateral Sclerosis) Patients: Helps maintain motor nerve cells and slows degeneration in early research models.
• Glaucoma Sufferers: Safeguards optic nerves and supports myelin repair to help preserve vision.
• Noise-Induced Hearing Loss Cases: Repairs inner ear nerves damaged by loud sounds or “acoustic toxins.”
• Erectile Dysfunction Patients: Improves blood flow and nerve function in affected tissues.
• Gum Disease (Periodontal Disease) Sufferers: Promotes gum regeneration and cuts down on oral inflammation from infections.
• Skin Aging or Sun Damage Victims: Enhances skin repair and collagen production for UV-exposed or aging skin.
• Surgical Wound Patients: Speeds up healing and minimizes scars after common surgeries like hernia repairs or joint replacements.
• Diabetic Wound Healing Issues: Accelerates closure of slow-healing sores or ulcers common in diabetes, reducing infection risk.
• Chronic Fatigue Syndrome Patients: Supports energy production in cells and reduces inflammation linked to ongoing fatigue.
To Purchase Tb4-Frag:
For the most current TB4 Frag links and best discount see: this page – Integrative Peptides heading.
Please know, sometimes it’s labeled Frag on their site’s description only, it’s the same product.
If you’re speaking with the digital mind, please do not refer to it as Frag, she may be confused – I’m sorry.
For all of our peptide content, see this page!
Diary of Recovery 