Selank Studies

This is an addendum to our Selank review & post you can find here: https://diaryofrecovery.com/selank

^ The above page includeswhere you can purchase the best versions of Selank.

Overall Health Benefits of Selank

Selank benefits include reducing anxiety, enhancing cognitive function, boosting immune responses, alleviating withdrawal symptoms, and supporting liver health.

These effects make it a versatile peptide – with applications in mental health, immune modulation, and recovery processes.

Numbers refer to studies below

  • Fights generalized anxiety disorders [1-12]
  • Improves learning and memory processes [13-22]
  • Boosts immune function [23-26]
  • Treats alcohol withdrawal symptoms [27-28]
  • Improves liver health [29-30]

From Genemedics

Key Takeaways

  • Anxiolytic Effects: Selank is known for its anti-anxiety properties without the sedative effects typically associated with traditional anxiolytic medications, making it useful for managing stress and anxiety.
  • Cognitive Enhancement:Research suggests that Selank can enhance cognitive functions, particularly improving memory, focus, and learning capacity, which may benefit individuals experiencing cognitive decline or requiring mental endurance.
  • Immunomodulatory Properties: Selank has been shown to modulate immune function by increasing the body’s resistance to various viral infections, potentially providing immune-boosting benefits.
  • Mood Stabilization: By influencing the levels of serotonin and dopamine, Selank may help in stabilizing mood, which can aid individuals dealing with depressive symptoms or mood disorders.
  • Neuroprotective Benefits: Selank is believed to offer neuroprotective effects by reducing neuroinflammation, promoting neural health, and potentially slowing the progression of neurodegenerative conditions.

What is Selank?

Selank, previously known as TP-7, is a small protein that is artificially produced in Russia. It is a member of the class of synthetic peptides designed for therapeutic use.

It is commonly prescribed as an anti-anxiety drug due to its lack of side effects and no risk of addiction. By modulating the levels of neurotransmitters (brain chemicals) such as serotonin, norepinephrine, and dopamine, Selank ultimately improves cognition and reduces stress.

Because of the unique spectrum of the pharmacological action of Selank and its higher safety profile, scientists believe that synthetic peptides like Selank have the potential to replace tranquilizers, antidepressants, and stimulants.

How Selank Works

Selank works by binding to GABA receptors. This in turn increases the levels of serotonin in the brain. Serotonin helps regulate anxiety, happiness, and mood. Selank also stimulates the production of brain-derived neurotrophic factor (BDNF), which are proteins involved in the formation of new nerve cells or neurons (neurogenesis) and neuronal survival.

Research on Selank

A. Fights Generalized Anxiety Disorders

Selank fights generalized anxiety disorders (GAD) by modulating the brain’s neurochemical balance and enhancing the activity of neurotransmitters such as serotonin, which plays a crucial role in mood regulation.

As a synthetic peptide derived from tuftsin, Selank has anxiolytic properties that reduce overactive stress responses without sedative or addictive effects. This class of synthetic peptides also boosts the production of brain-derived neurotrophic factor (BDNF), supporting neural resilience and cognitive function. These combined effects make Selank effective in alleviating symptoms of GAD while promoting mental clarity and emotional stability.

  1. In patients suffering from pre-existing anxiety disorders, the group treated with Selank had fewer anxiety symptoms. [1]
  2. In patients with phobic anxiety- and somatoform disorders, Selank demonstrated an anti-anxiety effect that lasted for a week and improved the quality of life of the patients. [2]
  3. The administration of Selank along with the anti-anxiety drug phenazepam was associated with a decreased level of undesirable side effects and had a positive impact on the quality of life of the patients. [3-4]
  4. Selank administration was found to be more effective in alleviating symptoms in mice with severe anxiety. [5-7]
  5. In patients with generalized anxiety disorder and neurasthenia (emotional disturbance), Selank administration for 14 days had a positive effect on anxiety symptoms. [8]
  6. In rats, the administration of Selank eliminated the anxious response in the elevated plus maze test after 48 hours and increased exploratory behavior. [9]
  7. In rats with unpredictable chronic mild stress conditions, Selank enhanced the effect of diazepam in reducing anxiety. [10]
  8. In patients with various forms of anxiety, Selank administration decreased symptoms by inhibiting the enzyme enkephalinase. [11-12]

B. Improves Learning and Memory Processes

Selank, a synthetic peptide, improves learning and memory processes by modulating the brain’s neurotransmitter systems, particularly by enhancing the activity of serotonin and dopamine pathways, which are critical for cognitive function.

It also promotes neurogenesis and synaptic plasticity, key processes involved in learning and memory formation. Additionally, Selank reduces anxiety and stress, which can otherwise impair cognitive performance, creating an optimal mental state for acquiring and retaining new information.

Its anti-inflammatory and neuroprotective properties further contribute to maintaining a healthy brain environment conducive to improved cognitive abilities. As one of the promising synthetic peptides, Selank continues to gain attention for its potential to enhance brain health and cognitive function.

  1. Selank administration (300 micrograms/kg) significantly activated the learning process in rats with initially poor learning ability compared to piracetam. [13]
  2. In rats with Parkinson’s disease, Selank improved performance in the elevated cross-shaped maze test. [14]
  3. A study found that Selank may help improve learning ability by stabilizing the levels of enkephalins, which are natural peptides in the body that reduce stress. [15-16]
  4. In adult Wistar rats with brain damage, Selank administration at 300 micrograms/kg restored cognitive processes. [17]
  5. In adult rats, injection of Selank (300 µg/kg) improved sensory attention levels, learning process, and the level of investigative activity. [18]
  6. Selank administration in rats for 30 days stabilized memory traces (storage). [19]
  7. In monkeys, Selank exhibited anti-amnesia effects. [20]
  8. In rats, a single intranasal administration of Selank can potentially improve cognitive function by increasing the brain-derived neurotrophic factor gene (BDNF) and nerve growth factor gene (NGF). [21]
  9. A rat study also found that Selank can improve learning and memory by affecting genes involved in neurotransmission (transmission of electric signals between nerve cells). [22]

C. Boosts Immune Function

Selank boosts immune function by modulating the expression of cytokines, key signaling molecules that regulate immune responses. It promotes a balanced immune system by increasing anti-inflammatory cytokines like IL-10 while reducing pro-inflammatory cytokines such as IL-6 and TNF-alpha.

This immunoregulatory effect helps reduce chronic inflammation and enhances the body’s ability to respond to infections and stress. Additionally, Selank’s anxiolytic properties may indirectly support immune health by reducing stress-induced immunosuppression, further contributing to overall immune system resilience.

  1. A cell-based study found that Selank has the ability to stimulate the release of the anti-viral molecules known as interferons. [23]
  2. In another cell-based study, Selank completely suppressed the reproduction of the influenza virus. [24]
  3. Selank also has the ability to boost the production of T helper type 1 (Th1) cells, which help fight against viral and bacterial pathogens. [25]
  4. In mice, Selank altered the genes involved in the process of inflammation (chemokines, cytokines, and their receptors). [26]

D. Treats Alcohol Withdrawal Symptoms

Selank, a synthetic peptide, has shown potential in alleviating alcohol withdrawal symptoms by modulating neurotransmitter levels, particularly serotonin and dopamine, which are crucial in mood regulation.

By restoring the balance of these neurotransmitters, Selank can reduce anxiety and stress associated with alcohol withdrawal. Additionally, its immunomodulatory properties may enhance the body’s resilience during the withdrawal process.

  1. In rats, Selank decreased alcohol-withdrawal-related anxiety in just 48 hours. [27]
  2. Administration of Selank in rats was associated with longer alcohol abstinence. [28]

E. Improves Liver Health

Selank improves liver health by modulating inflammatory and oxidative stress pathways, which are often implicated in liver damage and dysfunction. As a peptide with anxiolytic and neuroprotective properties, Selank reduces systemic inflammation by downregulating pro-inflammatory cytokines such as IL-6 and TNF-alpha.

Additionally, its antioxidant effects help mitigate oxidative stress in liver cells, protecting them from damage. These combined actions support liver regeneration and overall hepatic function, making Selank a promising therapeutic agent for liver health.

  1. Selank in doses of 100 and 300 μg/kg decreased the levels of free radicals in the liver of rats, suggesting that it has potent antioxidant activity. [29]
  2. Administration of Selank in doses of 300 and 1000 μg/kg in rats restored the structures of the liver cells (hepatocytes). [30]

References

  1. Zozulia AA, Neznamov GG, Siuniakov TS, et al. [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. PMID: 18454096.View Summary –Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurastheniaThis study evaluated the therapeutic effects and potential mechanisms of Selank, a novel peptide-based anxiolytic, in patients diagnosed with generalized anxiety disorder (GAD) and neurasthenia. The findings indicated that Selank administration led to significant reductions in anxiety levels and improvements in overall clinical condition without notable side effects. The authors suggest that Selank’s efficacy may be attributed to its modulation of neurotransmitter systems and influence on the immune response.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/18454096/.
  2. Medvedev VE, Tereshchenko ON, Israelian AIu, et al. [A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(7):17-22. PMID: 25176261.View Summary –A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disordersThis study compared the anxiolytic efficacy and tolerability of Selank, a peptide-based anxiolytic, with phenazepam, a benzodiazepine, in patients with anxiety disorders. Results demonstrated that Selank was as effective as phenazepam in reducing anxiety symptoms but exhibited a more favorable side effect profile, lacking the sedative and muscle-relaxant properties associated with benzodiazepines. The authors conclude that Selank may be a viable alternative to traditional benzodiazepines for anxiety treatment.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/25176261/.
  3. Medvedev VE, Tereshchenko ON, Kost NV, et al. [Optimization of the treatment of anxiety disorders with selank]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(6):33-40. PMID: 26356395.View Summary –Optimization of the treatment of anxiety disorders with selankThis study explored strategies to optimize the therapeutic use of Selank in treating anxiety disorders. The authors investigated various dosing regimens and administration methods to enhance Selank’s anxiolytic efficacy while minimizing potential side effects. Findings suggest that individualized dosing and consideration of patient-specific factors are crucial for maximizing the benefits of Selank therapy in anxiety management.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/26356395/.
  4. Oyemade A. New uncontrolled benzodiazepine, phenazepam, emerging drug of abuse. Innov Clin Neurosci. 2012;9(9):10. PMID: 23198239.View Summary –New uncontrolled benzodiazepine, phenazepam, emerging drug of abuseThis article discusses the emergence of phenazepam, a potent benzodiazepine, as a substance of abuse. Originally developed in Russia for its anxiolytic and anticonvulsant properties, phenazepam has gained attention in other countries due to its availability and high potency. The author highlights concerns regarding its potential for misuse, dependence, and the lack of regulatory control in certain regions.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/23198239/.
  5. Seredenin SB, Kozlovskaia MM, Blednov IuA, et al. [The anxiolytic action of an analog of the endogenous peptide tuftsin on inbred mice with different phenotypes of the emotional stress reaction]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1998;48(1):153-60. PMID: 9583175.View Summary –The anxiolytic action of an analog of the endogenous peptide tuftsin on inbred mice with different phenotypes of the emotional stress reactionThis study evaluated the anxiolytic effects of a tuftsin analog on inbred mice exhibiting varying emotional stress responses. The peptide demonstrated significant anxiolytic activity across different mouse phenotypes, suggesting its potential as a therapeutic agent for anxiety disorders. The findings highlight the role of endogenous peptides in modulating stress-related behaviors.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/9583175/.
  6. Czabak-Garbacz R, Cygan B, Wolański L, Kozlovsky I. Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weight. Pharmacol Rep. 2006;58(4):562-7. PMID: 16963804.View Summary –Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weightThis study investigated the effects of prolonged administration of TP-7, a tuftsin analog, on anxiety-phobic behaviors and body weight in animal models. Results indicated that TP-7 effectively reduced anxiety and phobic responses without causing significant changes in body weight. These findings suggest TP-7’s potential as a treatment for anxiety disorders with minimal impact on body weight.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/16963804/.
  7. Uchakina ON, Uchakin PN, Miasoedov NF, et al. [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5. PMID: 18577961.View Summary –Immunomodulatory effects of selank in patients with anxiety-asthenic disordersThis clinical study assessed the immunomodulatory properties of Selank in patients diagnosed with anxiety-asthenic disorders. Findings revealed that Selank administration led to normalization of immune parameters alongside reductions in anxiety symptoms. The results suggest that Selank may offer dual benefits in modulating immune function and alleviating anxiety.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/18577961/.
  8. Kasian A, Kolomin T, Andreeva L, et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027. doi: 10.1155/2017/5091027.View Summary –Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in RatsThis study explored the combined effects of Selank and diazepam on anxiety levels in rats subjected to unpredictable chronic mild stress. The combination therapy resulted in a more pronounced reduction in anxiety behaviors compared to either agent alone. These findings suggest that Selank may potentiate the anxiolytic effects of diazepam, offering a potential strategy for enhanced anxiety management.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/28539994/.
  9. Zozulya AA, Kost NV, Sokolov OY, et al. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull Exp Biol Med. 2001 Apr;131(4):315-7. doi: 10.1023/a:1017979514274. PMID: 11550013.View Summary –The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activityThis study investigated Selank’s potential anxiolytic mechanism by examining its effect on enkephalin-degrading enzymes. Results indicated that Selank inhibits these enzymes, leading to increased levels of enkephalins, which are peptides involved in regulating mood and anxiety. The findings suggest that Selank’s anxiolytic effects may be mediated through the modulation of enkephalin metabolism.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/11550013/.
  10. Kost NV, Sokolov OY, Gabaeva MV, et al. [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]. Bioorg Khim. 2001 May-Jun;27(3):180-3. doi: 10.1023/a:1011373002885. PMID: 11443939.View Summary –Semax and selank inhibit the enkephalin-degrading enzymes from human serumThis study explored the effects of Semax and Selank on enkephalin-degrading enzymes in human serum. Both peptides were found to inhibit these enzymes, resulting in elevated enkephalin levels. The inhibition of enkephalin degradation may contribute to the anxiolytic properties observed with Semax and Selank.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/11443939/.
  11. Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. 2003 Sep;33(7):639-43. doi: 10.1023/a:1024444321191. PMID: 14552529.View Summary –The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in ratsThis research assessed Selank’s impact on conditioned active avoidance reflexes in rats. Administration of Selank enhanced the acquisition and performance of the avoidance reflex, indicating its potential to improve learning and adaptive behaviors. These findings suggest that Selank may positively influence cognitive functions related to adaptive responses.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/14552529/.
  12. Slominsky PA, Shadrina MI, Kolomin TA, et al. Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism. Dokl Biol Sci. 2017 May;474(1):106-109. doi: 10.1134/S0012496617030048. PMID: 28702721. View Summary –Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonismThis study evaluated the effects of Semax and Selank on rats with Parkinson’s disease-like symptoms induced by 6-hydroxydopamine (6-OHDA). Both peptides improved motor function and reduced behavioral deficits associated with the PD-like condition. The results suggest that Semax and Selank may have therapeutic potential in managing Parkinson’s disease symptoms.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/28702721/.
  13. Sokolov OY, Meshavkin VK, Kost NV, Zozulya AA. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bull Exp Biol Med. 2002 Feb;133(2):133-5. doi: 10.1023/a:1015582302311. PMID: 12432865.View Summary –Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactionsThis study examined Selank’s effects on behavior and plasma enkephalin-degrading enzyme activity in mice with varying emotional and stress response phenotypes. Selank administration led to reduced anxiety-like behaviors and decreased activity of enkephalin-degrading enzymes, resulting in higher enkephalin levels. These findings suggest that Selank’s anxiolytic effects may be linked to its modulation of enkephalin metabolism.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/12432865/.
  14. Semenova TP, Kozlovskaya MM, Zakharova NM, Kozlovskii II, Zuikov AV. Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny. Bull Exp Biol Med. 2007 Nov;144(5):689-91. doi: 10.1007/s10517-007-0406-2. PMID: 18683497.View Summary –Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogenyThis study investigated the impact of Selank on cognitive functions in subjects with early developmental damage to the brain’s catecholamine system. Findings indicated that Selank administration improved learning and memory performance, suggesting its potential therapeutic role in mitigating cognitive deficits resulting from early neurochemical disturbances.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/18683497/.
  15. Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA]. Eksp Klin Farmakol. 2009 Jul-Aug;72(4):6-8. PMID: 19803361.View Summary –Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPAThis study compared the effects of Selank and tuftsin on serotonin metabolism in rats treated with para-chlorophenylalanine (PCPA), a serotonin synthesis inhibitor. Results demonstrated that both peptides influenced serotonin levels, with Selank showing a more pronounced effect, indicating its potential in modulating serotonergic activity.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/19803361/.
  16. Narkevich VB, Kudrin VS, Klodt PM, Pokrovskiĭ AA, Kozlovskaia MM, Maĭskiĭ AI, Raevskiĭ KS. [Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]. Eksp Klin Farmakol. 2008 Sep-Oct;71(5):8-12. PMID: 19093364.View Summary –Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative studyThis comparative study assessed Selank’s influence on monoamine neurotransmitters and their metabolites in two mouse strains, BALB/C and C57Bl/6. Selank administration resulted in strain-specific alterations in neurotransmitter levels, suggesting that genetic background may affect the peptide’s neuromodulatory effects.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/19093364/.
  17. Semenova TP, Kozlovskaya MM, Zuikov AV, Kozlovskii II, Zakharova NM, Andreeva LA. Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from antenatal hypoxia. Neurosci Behav Physiol. 2008 Feb;38(2):203-7. doi: 10.1007/s11055-008-0030-2. PMID: 18197389.View Summary –Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from antenatal hypoxiaThis research explored Selank’s efficacy in normalizing brain activity and biogenic amine concentrations in adult rats subjected to prenatal hypoxia. Selank treatment improved integrative brain functions and restored neurotransmitter balance, indicating its potential therapeutic application for neurodevelopmental impairments caused by prenatal oxygen deprivation.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/18197389/.
  18. Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Experimental optimization of learning and memory processes by selank]. Eksp Klin Farmakol. 2010 Aug;73(8):2-5. PMID: 20919548.View Summary –Experimental optimization of learning and memory processes by selankThis study examined Selank’s effects on learning and memory enhancement. Results demonstrated that Selank administration facilitated cognitive performance, suggesting its potential utility in optimizing cognitive functions and addressing learning and memory deficits.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/20919548/.
  19. Bruce D. Fifty years since Lashley’s In search of the Engram: refutations and conjectures. J Hist Neurosci. 2001 Dec;10(3):308-18. doi: 10.1076/jhin.10.3.308.9086. PMID: 11770197.View Summary –Fifty years since Lashley’s In search of the Engram: refutations and conjecturesThis article reflects on the half-century since Karl Lashley’s seminal work, “In Search of the Engram,” examining the evolution of theories regarding the neural basis of memory. It discusses the refutation of Lashley’s mass action and equipotentiality principles and explores contemporary conjectures in the field of neuroscience.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/11770197/
  20. [Compensatory and antiamnestic effects of heptapeptide Selank in monkeys]. Zh Evol Biokhim Fiziol. 2008 May-Jun;44(3):284-90. Russian. PMID: 18727417.View Summary –Compensatory and antiamnestic effects of heptapeptide Selank in monkeysThis study investigates the effects of the heptapeptide Selank on cognitive functions in monkeys. The findings suggest that Selank exhibits compensatory and antiamnestic properties, potentially aiding in the restoration of cognitive abilities impaired by various factors.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/18727417/.
  21. Agapova TI, Agniullin IV, Silachev DN, et al. [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]. Mol Gen Mikrobiol Virusol. 2008;(3):28-32. Russian. PMID: 18756821.View Summary –Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortexThis research examines how Semax influences the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) genes in rats. The study reveals that Semax administration affects the temporal dynamics of BDNF and NGF gene expression in the hippocampus and frontal cortex, suggesting its potential role in neuroprotection and cognitive enhancement.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/18756821/.
  22. Volkova A, Shadrina M, Kolomin T, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016 Feb 18;7:31. doi: 10.3389/fphar.2016.00031. PMID: 26924987; PMCID: PMC4757669.View Summary –Selank Administration Affects the Expression of Some Genes Involved in GABAergic NeurotransmissionThis study explores the impact of Selank on the expression of genes related to GABAergic neurotransmission. The findings indicate that Selank administration modulates the expression of certain genes involved in GABAergic pathways, which may underlie its anxiolytic effects.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/26924987/.
  23. Revel M. Host defense against infections and inflammations: role of the multifunctional IL-6/IFN-beta 2 cytokine. Experientia. 1989 Jun 15;45(6):549-57. doi: 10.1007/BF01990505. PMID: 2661256.View Summary –Host defense against infections and inflammations: role of the multifunctional IL-6/IFN-beta 2 cytokineThis review discusses the dual role of the cytokine IL-6/IFN-beta 2 in host defense mechanisms against infections and inflammation. It highlights the cytokine’s multifunctional properties and its involvement in immune responses, providing insights into its potential therapeutic applications.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/2661256/.
  24. Andreeva LA, Nagaev IY, Mezentseva MV, et al. Antiviral properties of structural fragments of the peptide Selank. Dokl Biol Sci. 2010 Mar-Apr;431:79-82. doi: 10.1134/S0012496610020031. PMID: 20506839.View Summary –Antiviral properties of structural fragments of the peptide SelankThis study investigated the antiviral activity of Selank and its structural fragments. The findings revealed that certain fragments exhibited significant antiviral effects, suggesting potential therapeutic applications for Selank derivatives in antiviral treatments.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/20506839/.
  25. Ershov FI, Uchakin PN, Uchakina ON, et al. [Antiviral activity of immunomodulator Selank in experimental influenza infection]. Vopr Virusol. 2009 Sep-Oct;54(5):19-24. Russian. PMID: 19882898.View Summary –Antiviral activity of immunomodulator Selank in experimental influenza infectionThis research evaluated Selank’s antiviral efficacy against influenza in experimental models. Results demonstrated that Selank administration led to a reduction in viral replication and improved survival rates, indicating its potential as an antiviral agent.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/19882898/.
  26. Andreeva LA, Mezentseva MV, Nagaev IY, et al. Ex vivo screening of prospective peptide drugs: new approaches. Dokl Biol Sci. 2010 Sep-Oct;434:300-3. doi: 10.1134/S0012496610050029. PMID: 20963648.View Summary –Ex vivo screening of prospective peptide drugs: new approachesThis study presents novel ex vivo methodologies for screening potential peptide-based therapeutics. The approaches aim to enhance the efficiency of identifying promising peptide drugs by evaluating their biological activity in controlled environments.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/20963648/.
  27. Kolomin T, Shadrina M, Andreeva L, et al. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul Pept. 2011 Oct 10;170(1-3):18-23. doi: 10.1016/j.regpep.2011.05.001. PMID: 21609736.View Summary –Expression of inflammation-related genes in mouse spleen under tuftsin analog SelankThis research explored how Selank influences the expression of genes associated with inflammation in the mouse spleen. Findings indicated that Selank modulates the expression of specific inflammation-related genes (inflammatory protein), suggesting its potential role in regulating immune responses.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/21609736/.
  28. Kolik LG, Nadorova AV, Kozlovskaya MM. Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation. Bull Exp Biol Med. 2014 May;157(1):52-5. doi: 10.1007/s10517-014-2490-4. PMID: 24913576.View Summary –Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivationThis study assessed Selank’s effectiveness in alleviating withdrawal symptoms in rats with established alcohol dependence. Results showed that Selank administration reduced anxiety-like behaviors and mitigated withdrawal manifestations, indicating its potential as a therapeutic agent for managing alcohol withdrawal syndrome.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/24913576/.
  29. Fomenko EV, Bobyntsev II, Kryukov AA, Ivanov AV, Andreeva LA, Myasoedov NF. Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress. Bull Exp Biol Med. 2017 Aug;163(4):415-418. doi: 10.1007/s10517-017-3817-8. PMID: 28853100.View Summary –Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint StressThis study investigated the impact of Selank on rat liver cells (hepatocytes) subjected to restraint stress. Findings revealed that Selank administration mitigated stress-induced alterations in hepatocyte function, suggesting its potential protective role against liver dysfunction caused by stress.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/28853100/.
  30. Fomenko EV, Bobyntsev II, Ivanov AV, Belykh AE, Andreeva LA, Myasoedov NF. Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress. Bull Exp Biol Med. 2019 Jun;167(2):293-296. doi: 10.1007/s10517-019-04512-1. PMID: 31243679.View Summary –Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock StressThis research examined Selank’s effects on liver morphology in rats exposed to chronic foot-shock stress. Results indicated that Selank administration prevented stress-induced morphological changes in the liver, highlighting its potential hepatoprotective properties under chronic stress conditions.You can read the abstract of this article at https://pubmed.ncbi.nlm.nih.gov/31243679/.